Our research aims at innovative mechanisms of action to treat neurogenic inflammation of the Neuro-Immuno-Cutaneous-Endocrine (NICE) system, and even prevent it. Within this system, constant communication between neuropeptides, cytokines, neurotransmitters, chemokines and other molecules ensures the homeostasis of the skin.
Different types of stress (diabetes, chemotherapy, scarring, etc.) can deregulate the NICE system and lead to neurogenic inflammation.
More specifically, our research aims to:
correct neurotransmission dysfunctions
inhibit the pro-inflammatory process
modulate immunological, endocrine and paracrine responses
improve cell metabolism, block the pathways of apoptosis
block the degeneration of the epidermal nerves, restore their myelination and stimulate the neo-growth of axons and dendrites